_____ the course of time, people learned to accept the changes.

• এখানে in the course of time এর বাংলা অর্থ হলো - কালক্রমে ,সময়ের সাথে সাথে,কালে; শেষপর্যন্ত; অবশেষে। অর্থাৎ as time passes.
example:
In the course of time, he became a famous writer.
Things will get better over the course of time.
In the course of time, people learned to accept the changes.
 
 SOURCE: A Passage to the English Language by S. M. Zakir Hussain